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JMC April 2026
Project type
Cover art illustration
Date
April 2026
Location
Boston
Link for the original paper
Engineered with molecular precision, BLU-654 is a highly potent, kinome-sparing inhibitor designed to selectively target the resistant KIT V654A mutation in gastrointestinal stromal tumors (GISTs), overcoming TKI resistance while minimizing off-target effects. The illustration was inspired by the chemical design of the molecule.
Link for the paper:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c03554
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